Concept

TGF-β: A Key Signal in Maintaining Bone Balance

Bone health relies on a continuous process of renewal, where old bone is replaced with new bone to maintain overall strength and structure.

Within this process, signaling factors such as TGF-β play an important role in supporting the body’s natural bone formation cycle and maintaining balance.

This highlights an important concept: healthy bones are not only about nutrient intake, but also about how the body regulates and responds through internal signaling.
Cell Biosci. 2013 Jan 15;3(1):4. doi: 10.1186/2045-3701-3-4.

Tribioflex® Patent Data

Key Postbiotic Strains in Tribioflex®
．Lactobacillus plantarum
．Bifidobacterium longum
Evaluating TGF-β Secretion Capacity in Chondrocytes
Indicates bone regeneration potential
Details
Evaluating Chondrocyte Proliferation
Indicates bone repair capacity
Details

Evaluating TGF-β Secretion Capacity in Chondrocytes

Study Protocol: Measurement of TGF-β Secretion in SW1353 Human Chondrocytes

Add 200 μL cell culture medium to each well of a 96-well plate.

Seed SW1353 chondrocytes at a density of 1 X 104 cells/well.

Incubate 24 hours, then add test substances.

Collect culture media after an additional 24 hours.

Quantify TGF-β levels using a commercial ELISA kit (Antigen-Antibody Binding).

Optimizing Postbiotic Performance with ProbioAid®

Postbiotics offer unique advantages, but their small particle size can lead to aggregation—affecting dispersion and formulation consistency.

To overcome this challenge, we developed ProbioAid®, a proprietary technology designed to enhance dispersion and improve stability.

By helping postbiotics remain evenly distributed, ProbioAid® supports more consistent performance and unlocks the full potential of PostbiotiX®-based formulations.

As PostbiotiX® continue to gain recognition, optimizing their delivery becomes essential—and ProbioAid® provides a smarter, more effective solution.

ProbioAid® Technology: >122.6% Higher Mobility Support for PostbiotiX® vs. Standard Postbiotics

Postbiotics promote joint health and mobility, but ProbioAid® technology significantly boosts PostbiotiX® bioactivity—maximizing endogenous tissue repair.

ProbioAid® Technology: More than doubling the bone matrix potency of PostbiotiX®

Not All Joint Ingredients are Created Equal

When assessed alongside common joint health ingredients, PostbiotiX® demonstrated among the highest TGF-β activity in joint tissue cells.

PostbiotiX® + Joint Actives:
A Synergy That Supports Mobility

* p < 0.05 vs. health ingredients group
The combination of PostbiotiX® with joint health ingredients demonstrates greater joint-supportive bioactivity than either ingredient used alone.

Evaluating Chondrocyte Proliferation

Study Protocol: Measurement of Cell Proliferation in SW1353 Human Chondrocytes

Add 200 μL cell culture medium to each well of a 96-well plate.
Seed SW1353 chondrocytes at a density of 1 X 104 cells/well
Incubate 24 hours, then add test substances.
Perform cell counting under a microscope after an additional 24 hours.

PostbiotiX® + Joint Actives:
Synergistic Joint Structure Support

* p < 0.05 vs. health ingredients group
The combination of PostbiotiX® with joint health ingredients is associated with greater support for maintaining joint structure — beyond what joint health ingredients provide alone.
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*1. These statements have not been evaluated by official authority. This product is not intended to diagnose, treat, cure or prevent any disease. 2. This information is intended for use out of the US only. Some statements and claims enclosed may not be compliant with US regulations.